vs Omeprazole (Study)

Pantoprazole vs omeprazole when treating acute gastric ulcers


Pantoprazole is actually a newer substitute for benzimidazole, which itself is a powerful inhibitor of the secretion of gastric acid by its action upon H+,K(+)-ATPase.


Both pantoprazole and omeprazole are proton pump inhibitors, and they were compared in a double-blind randomized study that had two hundred and nineteen patients that had gastric ulcers that were benign. They would receive either 20 mg of omeprazole (n=73) or 40 mg of pantoprazole (n=146) one time every day prior to breakfast for four weeks straight. If the ulcer did not heal, the period was extended for another four weeks.


After four weeks of treatment, the ulcer was completely healed in 88% of protocol-correct patients that were given pantoprazole, while 77% of those given omeprazole were completely healed. This produced a between-group difference of P < 0.05. After those who needed eight weeks, those given pantoprazole were at 97% healed and those given omeprazole were 96% healed (not a significant difference).

When examining patients who had pain in their ulcer before getting treated:

After two weeks: 79% of pantoprazole takers were pain free, compared to 68% of the omeprazole takers.

After 4 weeks: 88% of pantoprazole takers were pain free, compared to 81% of omeprazole takers.

Significant improvement in some of the other gastrointestinal symptoms was noted for both medications. Only a small sample of patients (10%) from each medication claimed adverse symptoms. Both treatments caused some slight increases in fasting serum gastrin levels at four and eight weeks.


A 40 mg dose of pantoprazole once every day in the morning is the most effective and best tolerated treatment for an acute, benign gastric ulcer. They were both very similarly safe in the treating of a gastric ulcer.

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